Insulin-like Growth Factor I in Pregnancy and Maternal Risk of Breast Cancer
نویسندگان
چکیده
منابع مشابه
Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer.
BACKGROUND Elevated serum concentrations of insulin-like growth factor (IGF)-I have been associated with increased risk of developing breast cancer. Previously, we reported a similar association in samples obtained during pregnancy. This study was conducted to further characterize the association of IGF-I during pregnancy with maternal breast cancer risk. METHODS A case-control study was nest...
متن کاملInsulin-like growth factor I in pregnancy and maternal risk of breast cancer.
BACKGROUND The role of insulin-like growth factor (IGF)-I in breast cancer remains controversial, despite numerous reports on the association of the hormone with breast cancer or high-risk mammographic densities. We hypothesized that exposure to elevated IGF-I during early pregnancy, a period characterized by intense cell proliferation in the breasts and in the presence of high concentrations o...
متن کاملInsulin-like growth factor-I and risk of breast cancer.
Background :-Breast cancer is responsible for the death of millions of women worldwide every year. It is widespread in the world and Iraq that become a genuine problem for public health. The etiology of the disease is unknown. Genetic and hormonal factors are involved in the development of breast cancer and progression of the disease. Insulin like growth factor-ӏ (IGF-ӏ) have been implicated as...
متن کاملInsulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
JNCI Vol. 101, Issue 1 | January 7, 2009 Breast cancer is the most common malignancy among women in the United States. Approximately 182 000 new cases of breast cancer and more than 40 000 breast cancer – related deaths are expected in 2008 ( 1 ). One of the established risk factors for postmenopausal breast cancer, obesity ( 2 – 7 ), has reached epidemic proportions in the United States, and w...
متن کاملRe: Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.
BACKGROUND The positive association between obesity and postmenopausal breast cancer has been attributed, in part, to the fact that estrogen, a risk factor for breast cancer, is synthesized in adipose tissue. Obesity is also associated with high levels of insulin, a known mitogen. However, no prospective studies have directly assessed associations between circulating levels of insulin and/or in...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2006
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-06-0625